As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid, molecular formula is C17H14N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C17H14N4O2
Example 13; Preparation of 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoyl chloride, dihydrochloride of the formula (X-Cl).2HCl:Thionyl chloride (1400 ML) was added to 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylbenzoic acid of formula X (39 gms). This mixture was heated to 60-70 C. and stirred for 10-12 hours. The reaction mixture was then cooled to 30-27 C. The obtained slurry was filtered and the solid was washed with dichloromethane. The wet product was dried at 55-60 C. under reduced pressure. Dry wt: 140 gm Yield: 95.4 Purity: above 98% by HPLC Hydrochloride content (by Argentometry titration): 27.48%
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Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; US2010/16590; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem