Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127406-56-8, name is 4-Pyridin-2-yl-benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Pyridin-2-yl-benzaldehyde
To a solution of 3, 4, 5-piperidinetriol, 2- (hydroxymethyl)-, (2S, 3R, 4R, [5S)] [(50MG,] 0. [31MMOL)] in methanol [(2ML)] was added 4- (2-pyridyl) benzaldehyde (280mg, 1. [53MMOL).] The mixture was stirred for 5 min until fully dissolved. The pH was adjusted to 5 by addition [OF METHANOLIC HCI (1M),] then (polystyrylmethyl) trimethylammonium cyanoborohydride (180mg, 0. [78MMOL)] was added. The resultant mixture was stirred at room temperature for 48 [H.] The crude reaction mixture was purified using a plug of acidic Dowex 50X4-200 resin [(1.] [5G),] which had been pre-washed with 10% aqueous hydrochloric acid, followed by water then methanol. The resin was eluted with methanol [(25ML)] to remove all non-basic side products. The desired compound was then eluted using a solution of 2: 2: 1 [METHANOL/WATER/AMMONIUM] hydroxide [(50ML).] The solution was concentrated to a small volume [(~LML)] and freeze dried. The resulting residue was crystallised from [METHANOL/ETHYL] acetate to give the title product (80mg, [78%).’H] NMR (d4-methanol) 8 2.63 [(1H,] dd, [J =] 9.6, 12. [2 HZ),] 2.73 [(1H,] dd, J = 5.1, 12. [2 HZ),] 3.11 [(1H,] m), 3.40 [(1H,] t, J [= 9.] 0 Hz), 3.53 [(1H,] m), 3.78 [(1H,] dd, J = 5.3, 9.0 Hz), 3.88-4. 03 (4H, m), 7.35 [(1H,] m), 7.50 [(2H,] d, J [= 8.] 3 Hz), 7.82-7. 90 (4H, m), 8.59 [(1H,] d, J = 4.9 Hz). MS [M/Z] 331.3 (M+H) +.
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Reference:
Patent; OXFORD GLYCOSCIENCES (UK) LTD; WO2004/7453; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem