Application of 115170-40-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115170-40-6 as follows.
To a solution of 5-bromo-2,3-dihydro-1 H-pyrrolo(2,3-b)pyridine (CAS Number 1 15170-40-6; 0.300 g, 1 .507 mmol) in 1 ,4-dioxane:water (1 : 1 , 8 ml) were added phenylboronic acid (0.294 g, 2.412 mmol) and K2CO3 (0.624 g, 4.52 mmol) at rt. The reaction mixture was degassed for 30min before addition of Pd(PPh3)4 (0.087 g, 0.075 mmol) thenheated at 80C for 1 h. The reaction was cooled to rt, poured into water (100 ml) and extracted with EtOAc (3 x 50 ml). The combined organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure yielding 5-phenyl-2,3-dihydro-1 H-pyrrolo[2,3-b]pyridine (0.440 g, 2.24 mmol). MS: ES+ 197.1 .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115170-40-6, its application will become more common.
Reference:
Patent; MISSION THERAPEUTICS LIMITED; STOCKLEY, Martin Lee; KEMP, Mark Ian; MADIN, Andrew; (167 pag.)WO2018/65768; (2018); A1;,
Pyridine – Wikipedia,
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