In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 851607-27-7, name is 5-Bromo-4-chloro-2-methoxypyridine, the common compound, a new synthetic route is introduced below. Product Details of 851607-27-7
A mixture of 5-bromo-4-chloro-2-methoxypyridine (416 mg),ethyl (6-(piperidin-4-ylmethoxy)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)acetate (938 mg), potassium carbonate (775 mg)and DMSO (10 mL) was stirred at 100C for 40 hr. The reactionmixture was added to water, and the mixture was extracted with ethyl acetate. The organic layer was separated, washedsuccessively with water and saturated brine, dried overanhydrous magnesium sulfate and concentrated under reducedpressure. The residue was purified by silica gel columnchromatography (ethyl acetate/hexane) to give the title35 compound ( 396.0 mg) . MS: [M+H] + 520. 1.
The synthetic route of 851607-27-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; SCOHIA PHARMA, INC.; MIWATASHI, Seiji; MIYAMOTO, Yasufumi; WATANABE, Koji; YOSHITOMI, Yayoi; HITOMI, Yuko; AIDA, Jumpei; TAKAKURA, Nobuyuki; FURUKAWA, Hideki; NOGUCHI, Naoyoshi; HIRATA, Yasuhiro; KASAI, Shizuo; KOBAYASHI, Toshitake; MAEKAWA, Tsuyoshi; SASAKI, Satoshi; MATSUMOTO, Shigemitsu; (190 pag.)WO2018/182050; (2018); A1;,
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