Related Products of 1003711-85-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1003711-85-0, name is 5-Bromo-4-chloro-2-methylpyridine, molecular formula is C6H5BrClN, molecular weight is 206.47, as common compound, the synthetic route is as follows.
4-Chloro-2-fluoro-N-(2-methoxy-phenyl)-N-methyl-5-(4,4,5,5- tetramethyl-[1 ,3]dioxolan-2-yl)-benzenesulfonamide (57 mg, 0.125 mmol), 5-bromo-4- chloro-2-methyl-pyridine (21 mg, 0.1 mmol), Pd(Ph3P)4 (12 mg, 0.01 mmol), K2CO3 (69 mg, 0.5 mmol) in a mixture of dioxane (1.5 ml.) and water (0.15 ml.) was degassed with N2 for 5 min. The reaction vessel was sealed and heated at 85 0C for 14 hrs. After the filtration, the mixture was purified by prep. LCMS to afford 4-chloro-5-(4- chloro-6-methyl-pyridin-3-yl)-2-fluoro-N-(2-methoxy-phenyl)-N-methyl- benzenesulfonamide 3-1. MS: 454.7 (M+H)+; tR = 7.77 min (method 2). NMR (CDCI3), delta, 8.350 (1 H, s), 7.549(1 H, d, J=6.9Hz), 7.257-7.436 (5H, m), 6.932 (1 H, m), 6.817 (1 H, m), 3.513 (3H, s), 3.389 (3H, d, J=2.1 Hz), 2.656 (3H, s).
The chemical industry reduces the impact on the environment during synthesis 1003711-85-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2008/124614; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem