New downstream synthetic route of 5-Cyclopropyl-2-fluoropyridine

Statistics shows that 1034467-80-5 is playing an increasingly important role. we look forward to future research findings about 5-Cyclopropyl-2-fluoropyridine.

Application of 1034467-80-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1034467-80-5, name is 5-Cyclopropyl-2-fluoropyridine, molecular formula is C8H8FN, molecular weight is 137.15, as common compound, the synthetic route is as follows.

Preparation 155-Cyclopropyl-2-fluoro-3-iodo-pyridineCool a solution of 5-cyclopropyl-2-fluoro-pyridine (1.3 g, 9.5 mmol) in THF (20 mL) to -75 0C in a dry ice-acetone bath under nitrogen. Add lithium diisopropylamide (2 M in THF, 6 mL, 12 mmol) during a period of 30 min. Stir the mixture for another 3 h before adding iodine (2.9 g, 11.4 mmol, dissolved in 50 mL of THF). Keep stirring for 2 more hours before adding water (100 mL) to the mixture. Then allow to warm to RT during 1 h under stirring. Treat the mixture with a saturated sodium thiosulfate solution (50 mL). Extract the solution with ether. Concentrate the solution in vacuo. Purify by column chromatography (hexane-^ 20% ethyl acetate in hexane) to afford the title compound as a yellow oil (1.7 g, 68 %). 1H NMR (400 MHz- CDCl3) delta 7.99 (d, J= 3 Hz, IH), 7.39 (td, J= 3, 5 Hz, IH), 6.79 (dd, J= 3, 8 Hz, IH), 0.96-1.02 (m, 2H), 0.63-0.69 (m, 2H).

Statistics shows that 1034467-80-5 is playing an increasingly important role. we look forward to future research findings about 5-Cyclopropyl-2-fluoropyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2008/144222; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem