Electric Literature of 74784-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a sealed tube, dissolve 4-(5-chloro-l,8-naphthyridin-2-yl)-5-(trifluoromethyl)- pyrimidin-2-ol (237 mg, 0.725 mmol), 2-amino-5-trifluoromethyl-pyridme (176 mg, 1.09 mmol), and CS2CO3 (709 mg, 2.18 mmol) in dry dioxane (7 mL). Bubble argon through the solution for five minutes. Add Pd2dba3 (66 mg, 0.0725 mmol) and xantphos (42 mg, 0.0725 mmol) and bubble argon through the solution for an additional five minutes. Seal the tube and heat at HOC overnight. Cool the mixture and dilute with Et2O. Filter the solution through Celite. Discard the filtrate. Wash the Celite bed with MeOH. Concentrate the methanolic filtrate under reduced pressure. Purify the crude residue by silica gel chromatography eluting with CH2Cl2ZMeOH (90/10) to yield the title compound. LC/MS (MH+) 453.10.
According to the analysis of related databases, 74784-70-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NEUROGEN CORPORATION; WO2006/81388; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem