52334-81-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52334-81-3, name is 2-Chloro-5-trifluoromethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
Step 1; Preparation of 2-cyano-5-trifluoromethylpyridine; To 150ml N,N-dimethylformamide solution containing 15.0 g of 2-chloro-5-trifluoromethylpyridine were added 19.4 g of zinc cyanide and 9.6 g of tetrakistriphenylphosphine palladium, and the mixture was stirred under nitrogen atmosphere at 80C for 3 hours. After completion of the reaction, the reaction mixture was cooled to room temperature by allowing to stand, poured into 300 ml of dil. aqueous ammonia, and extracted with 300 ml of diethyl ether. The organic layer was washed with 200 ml of a saturated saline solution, then dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure, and the residue was purified by distillation under reduced pressure (96.0 to 99.0C/40 mmHg) to obtain 10.9 g of the the objective product as white crystals. Melting point: 36.0 to 38.0C 1H NMR (CDCl3, Me4Si, 300MHz) delta 9.00 (bs, 1H), 8.13 (dd, J=8.3, 2.1Hz, 1H), 7.87 (d, J=8.3Hz, 1H).
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Reference:
Patent; Nissan Chemical Industries, Ltd.; EP1671941; (2006); A1;,
Pyridine – Wikipedia,
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