In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52605-96-6, name is 2-Chloro-3-methoxypyridine, the common compound, a new synthetic route is introduced below. Product Details of 52605-96-6
The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3-equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 100 C. until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74 C.; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29% yield for two steps).1H NMR (300 MHz, CDCl3) delta 7.65 (dd, 1 H, J1=5.1 Hz, J2=1.5 Hz), 6.96(dd, 1 H, J1=7.5 Hz, J2=1.5 Hz), 6.76(dd, 1 H, J1=5.1 Hz, J2=7.7 Hz), 3.95 (s, 3 H), 3.80 (s, 3 H).
The synthetic route of 52605-96-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BioNumerik Pharmaceuticals, Inc.; US2008/261919; (2008); A1;,
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