Reference of 65189-15-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 65189-15-3, name is 5,6-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.
Example 3 5-Chloro-2-methylthio-3-pyridinecarbonitrile STR11 5,6-Dichloro-3-pyridinecarbonitrile (1.73 g, 0.01 mol) was dissolved with stirring in dimethyl sulphoxide (25 mL) and sodium methanethiolate (0.77 g, 0.011 mol) added. The reaction mixture was stirred at room temperature for two hours and poured onto ice (100 g). The mixture was extracted with dichloromethane (50 mL), and the organic extract washed with water (100 mL), and brine, and dried over anhydrous sodium sulphate. Evaporation of the solvent under reduced pressure and recrystallisation of the residue from ethyl acetate:hexane gave the desired product (1.3 g, 71%) as a cream solid, MP 147-9 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65189-15-3, 5,6-Dichloronicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Kirby; Neil V.; Morrison; Irene M.; Canada; Emily J.; Pieczko; Mary E.; Gustafson; Gary D.; Cooper; David H.; Adamski; Jenifer L.; Mathieson; John T.; Galka; Christopher S.; US6133294; (2000); A;,
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