Adding a certain compound to certain chemical reactions, such as: 1256810-26-0, 6-Bromo-3-methoxypicolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Bromo-3-methoxypicolinic acid, blongs to pyridine-derivatives compound. Safety of 6-Bromo-3-methoxypicolinic acid
To a solution of (IS, 2S)- 1 -A?-(6-fluoro- 1 ,3-benzothiazol -2-yl)cyclopentane- 1 ,2-di amine hydrochloride (Intermediate 1; 343 mg, 1.19 mmol) in dry DCM (4 ml) and THF (2 ml) was added 6-bromo-3-methoxypyridine-2-carboxylic acid (CAS number 1256810-26-0; (0506) 349 mg, 1.50 mmol), HATU (680 mg, 1 .79 mmol) and tri ethyl amine (498 mu, 3.58 mmol) The reaction mixture was stirred at room temperature for 72 hours then partitioned between DCM and a saturated solution of sodium bicarbonate. The organics were filtered through a hydrophobic frit and concentrated in vacuo. The caide material was purified by column chromatography (silica, 0 – 100 % ethyl acetate / petrol then 0 – 30 % methanol / ethyl acetate) and then further purified by column chromatography (silica, 0 – 100 % ethyl acetate / petrol then 0 – 30 % methanol / ethyl acetate) to afford the title compound. (0507) 1H NMR (DMSO-t) delta ppm 1.50-1.72 (m, 2 H), 1.69-1.78 (m, 2 H), 2,05-2, 18 (m, 2 H), 3.72 (s, 3 H), 4.14-4.25 (m, 2 H), 6.99-7.08 (m, 1 H), 7.29-7.34 (m, 1 H), 7.50-7.69 (m, 3 H), 8, 13-8,21 (m, 1 H), 8,54-8,62 (m, 1 H) (0508) MS ES+: 466 / 468
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1256810-26-0, 6-Bromo-3-methoxypicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; FUJIMOTO, Tatsuhiko; ROBINSON, John Stephen; WO2015/124934; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem