New downstream synthetic route of 6-Chloro-N-methylnicotinamide

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 54189-82-1, 6-Chloro-N-methylnicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H7ClN2O, blongs to pyridine-derivatives compound. COA of Formula: C7H7ClN2O

To a solution of 3-cyclobutyl-3-azaspiro[5.5]undecan-9-ol (0.44 mmol) in DMSO (4 ml), sodium hydride (65% disp. in mineral oil, 0.8 mmol) is added. After 30 min, 6-chloro-N-methyl-nicotinamide (0.26 mmol) is added and the reaction mixture is heated to 120 C. overnight. The reaction is allowed to cool to rt and then partitioned between EA and water. The EA layer is separated and the water layer is extracted with EA. The combined organic layer is washed with water, and then with brine, dried (Na2SO4) and filtered. The mixture is concentrated in vacuo and the residue is purified with PTLC to afford the title compound. MS (Method 1): 358.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; Xu, Yuelian; Caldwell, Timothy M.; Xie, Linghong; Chenard, Bertrand L.; US2008/247964; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem