Synthetic Route of 898746-42-4 , The common heterocyclic compound, 898746-42-4, name is 6-Fluoro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
6-Fluoro-1H-pyrrolo[2,3-b]pyridine (2.50 g, 18.36 mmol)Soluble in DMF (50mL),Cool to 0 C,Then add bromine to it(3.20g, 20.00mmol)DMF (20 mL) solution,After the dropwise addition was completed, the resulting reaction solution was stirred at room temperature for 2 hours.Then water (100 mL) was added and a large amount of solid precipitated.Filter under reduced pressure, and the filter cake was washed with water (30 mL×2).Then dried under vacuum at 60 C for 24 hours.The title compound was obtained as a white solid (3.44 g, 87%).
The synthetic route of 898746-42-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; Nie Biao; Xu Juan; Yan Huan; Chen Jianping; (90 pag.)CN108727369; (2018); A;,
Pyridine – Wikipedia,
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