With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, molecular formula is C6H5NO2, molecular weight is 123.11, as common compound, the synthetic route is as follows.Recommanded Product: 6-Oxo-1,6-dihydropyridine-3-carbaldehyde
Example 22: [Show Image] To a solution of intermediate 22b (295 mg, 0.720 mmol) in acetonitrile (20 mL) and acetic acid (200 muL) was added 6-hydroxynicotinaldehyde (87 mg, 0.708 mmol). The reaction mixture was stirred vigorously at reflux temperature overnight. The solvent was removed under reduced pressure. The crude product was purified by preparative LC-MS. The pure product (54 mg, orange oil) was dissolved in methanol (2 mL) and 1 M HCl in diethyl ether (110 muL, 0.110 mmol) was added. The solvents were removed under reduced pressure. The product was taken up in water (3 mL) and lyophilized.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem