Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below., Quality Control of 2-Oxo-1,2-dihydropyridine-3-carboxylic acid
To a solution of 2-hydroxynicotinic acid 1 (18.98 g, 0.136 mmol) in glacial acetic acid was added bromine (8.4 ml, 0.163 mmol). The reaction mixture was stirred at 80 C overnight and monitored by TLC to confirm its completion. The reaction mixture was then evaporated in vacuo and the resulted precipitate was collected, washed with cold water and filtered to furnish the compound 2 in good yields. (22.7, 76.6%). 1H-NMR (300 MHz, CDCl3) delta 8.25 (d, J = 2.4 Hz, 1H), 8.34 (d, J = 2.4 Hz, 1H), 13.8 (brs, 1H).
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Reference:
Article; Liu, Linyi; Li, Xinyu; Cheng, Yu; Wang, Lianjian; Yang, Huizhu; Li, Jiurong; He, Siying; shuangjie Wu; Yin, Qianqian; Xiang, Hua; European Journal of Medicinal Chemistry; vol. 164; (2019); p. 304 – 316;,
Pyridine – Wikipedia,
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