Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 625-82-1, is researched, Molecular C6H9N, about Highly Phototoxic Transplatin-Modified Distyryl-BODIPY Photosensitizers for Photodynamic Therapy, the main research direction is preparation transplatin distyryl BODIPY PDT photosensitizer cancer PDT; Cancer; intramolecular charge transfer; photophysics; photosensitizer; singlet oxygen.Product Details of 625-82-1.
We report the synthesis of the first transplatin-BODIPY conjugates for application in photodynamic therapy (PDT). The distyryl BODIPYs containing two iodine atoms were designed to absorb in the red region, easily undergo intersystem crossing for efficient singlet oxygen generation, and addnl. offer the possibility for coordination with mono-activated transplatin. We were able to demonstrate that coordination of the BODIPYs with a mono-activated transplatin increases the phototoxic index of the photosensitizers significantly, giving rise to highly phototoxic distyryl BODIPY derivatives, of which one was shown to have the highest ever reported phototoxic index against any cell line. Furthermore, the photophys. mechanism of singlet oxygen generation in distyryl BODIPYs undergoing intramol. charge transfer was studied exptl. and using time-dependent d. functional theory.
《Highly Phototoxic Transplatin-Modified Distyryl-BODIPY Photosensitizers for Photodynamic Therapy》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,4-Dimethyl-1H-pyrrole)Product Details of 625-82-1.