As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6318-51-0, name is (4-Chlorophenyl)(pyridin-2-yl)methanone, molecular formula is C12H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (4-Chlorophenyl)(pyridin-2-yl)methanone
To a stirred solution of (4-chlorophenyl) (pyridin-2-yl) methanone (3.5 g, 16.12 mmol) in MeOH (35 mL) under argon atmosphere was added hydroxyl amine hydrochloride (3.36 g, 48.35 mmol, 3 equiv) at 0 C. The reaction mixture was warmed to room temperature and stirred for 12 h. After completion, the volatiles were removed under reduced pressure and ethyl acetate was added to the residue. The organic layer was washed with saturated NaHCO3solution, dried over sodium sulfate, filtered and the concentrate under reduced pressure. The crude was triturated with n-hexane to afford 3.1 g of (4-chlorophenyl) (pyridin-2-yl) methanone oxime (Yield = 83%). ESI + MS: m/z 233 ([M + Hj).
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Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
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