New downstream synthetic route of 67367-24-2

With the rapid development of chemical substances, we look forward to future research findings about 67367-24-2.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 67367-24-2, name is Methyl 4-hydroxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H7NO3

Reference example 30: methyl 5-bromo-4-hydroxypyridine-3-carboxylate To a suspension of methyl 4-hydroxypyridine-3-carboxylate (CASNo.67367-24-2) (1.96 g) in acetonitrile (20 mL)/acetic acid (4 mL) was added N-bromosuccinimide (CASNo.128-08-5) (2.39 g) at room temperature, and the mixture was stirred at 60 degrees C for 4 hours followed by concentration. To the obtained residue was added acetone, and the mixture was stirred for 5 min. The insoluble matter was collected by filtration to obtain the title compound having the following physical property values. Description: white powder; TLC: Rf 0.53 (ethyl acetate : methanol = 4 : 1);

With the rapid development of chemical substances, we look forward to future research findings about 67367-24-2.

Reference:
Patent; ONO Pharmaceutical Co., Ltd.; ISHIDA, Akiharu; MATSUSHITA, Takeshi; SEKIGUCHI, Tetsuya; KOMAGATA, Tatsuya; NISHIO, Takuya; EP2871179; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem