New downstream synthetic route of 6980-09-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6980-09-2, 2-Chloro-4-methoxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 6980-09-2 ,Some common heterocyclic compound, 6980-09-2, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-methoxy-2-(4-methyl-1H-imidazol-1-yl)-3-nitropyridine To a mixture of 2-chloro-3-nitro-4-methoxypyridine (2.0 g, 10.6 mmol) and 4-methylimidazole (1.3 g, 15.9 mmol) in 20 mL of DMF was added freshly powdered KOH (0.9 g, 15 mmol). The resulting mixture was stirred at rt for 16 h. The reaction was poured into water and extracted with ethyl acetate (3*). Standard work-up followed by column chromatography using 50% ethyl acetate in hexane provided the product (0.65 g, 28% yield). MS (ESI) 235.0 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6980-09-2, 2-Chloro-4-methoxy-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; US2010/120762; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem