Application of 76006-11-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76006-11-6, name is 7-Chloro-1H-pyrazolo[3,4-c]pyridine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Amixture of 7-chloro-1H-pyrazolo[3,4-c]pyridine (200 mg, 1.30 mmol) and piperazine (1.12g, 13.02 mmol) was dissolved in EtOH (20 mL). The mixture was stirred at 80 C for 8 h under microwave radiation. The solution was purified by prep-HPLC (Boston C18 21*250mm 10.im, Mobile phase: A: 0.1 % trifluoroacetic acid; B: acetonitrile) to afford 7-(piperazin-1-yl)-1H-pyrazolo[3,4-c]pyridine (100 mg, 0.493 mmol) as a white solid. MS (EI, m/z): 204.2 [M+H]t ?HNMR (500 MFIz, DMSO-d6) 13.72 (s, 1H), 8.15 (s, 1H), 7.64 (d, J= 5.6 Hz, 1H), 7.04 (d, J = 5.4 Hz, 1H), 3.64 (s, 4H), 2.75 (d, J= 108.1 Hz, 4H).
According to the analysis of related databases, 76006-11-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; O’NEILL, David John; SAIAH, Eddine; KANG, Seong Woo Anthony; BREARLEY, Andrew; BENTLEY, Jonathan; (565 pag.)WO2018/89433; (2018); A1;,
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