Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77145-64-3, name is 2-Chloro-6-(methylthio)pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H6ClNS
(Example 15) 2-chloro-6-methylthiopyridine (1.00 g, 6.26 mmol) and succinimide (62 mg, 0.63 mmol) were mixed with toluene (20 mL). 10% aqueous solution of sodium hypochlorite (11.6 g, 15.7 mmol) was added dropwise to the mixture at 0 to 5C, and it was stirred for 1 hour. After that, ethyl acetate (10 mL), water (10 mL) and sodium sulfite (473 mg, 3.76 mmol) were added to the mixture, and it was stirred. After stirring and separation, an organic layer was concentrated under reduced pressure, and the residue was subjected to purification by means of a silica gel column to obtain 2-chloro-6-methylsulfonylpyridine (1.18 g, yield: 98%). 1H-NMR (300MHz, CDCl3) delta 3.26 (3H, s), 7.57-7.60 (1H, m), 7.90-8.05 (2H, m)
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Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2003116; (2008); A2;,
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