Application of 83393-46-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 83393-46-8, name is 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone, molecular formula is C9H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(E)-3-chloro-3-(lH-pyrrolo[2,3-b]pyridin-3-yl)acrylaldehyde:; Phosphorous oxychloride (3.7 mL, 40 mmol) was added dropwise to DMF (6.2 mL, 80 mmol) at 0 C. The reaction mixture was let warm to room temperature and stirred for 15 minutes. 1-(lH-Pyffolo[2,3-b]pyridin-3-yl)-ethanone was added in DMF (20 mL) and the reaction heated to 60 C for 4 hours, cooled to 0 C and 150 mL of saturated NaOAc solution added. The reaction mixture was heated briefly to 50 C and then extracted with EtOAc. The organic layer was washed with brine, dried over sodium sulfate and concentrated to an oil which contains impure product. Upon standing a solid precipitated from the aqueous layer to give 0.9 g of a brown solid, 4.3 mmol, 22% yield.
According to the analysis of related databases, 83393-46-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/103050; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem