New downstream synthetic route of 84703-18-4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 84703-18-4, 5-Bromo-2-chloro-6-methylnicotinonitrile, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 84703-18-4, Adding some certain compound to certain chemical reactions, such as: 84703-18-4, name is 5-Bromo-2-chloro-6-methylnicotinonitrile,molecular formula is C7H4BrClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84703-18-4.

General procedure: A mixture of 10a-10k (1 mmol), methyl thioglycolate (159 mg,1.5 mmol) and Et3N (152 mg, 1.5 mmol) in 10 mL of methanol was stirred at 80 C for 6-8 h. Methanol was removed under vacuum.The residuewas purified by column chromatography to provide thetitle compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 84703-18-4, 5-Bromo-2-chloro-6-methylnicotinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Yan; Li, Min; Li, Bowen; Zhang, Shun; Su, Aoze; Xing, Yongning; Ge, Zemei; Li, Runtao; Yang, Baoxue; European Journal of Medicinal Chemistry; vol. 172; (2019); p. 131 – 142;,
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