Reference of 853909-08-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 853909-08-7, name is 5-Ethynyl-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Under argon, to a solution containing 3-aminoquinuclidine bishydrochloridesalt 2 (212 mg, 1.00 mmol) and 1H-imidazole-1-sulfonyle azide 1 (232 mg, 1.10 mmol) in MeOH (6 mL) wasportion wise added K2CO3 (415 mg, 3.00 mmol) and next a catalyticamount of CuSO4, 5H2O (25 mg, 0.10 mmol). The reaction mixturewas stirred at room temperature for 6 h and then concentratedunder reduced pressure. The crude solid was solubilized in Et2O(10 mL), filtered and the precipitate washed with an additionalamount of Et2O (10 mL). The combined organic layers were reducedunder reduced pressure and the (R) intermediate 3a used in thenext step. After addition of MeOH (6 mL), the desired terminalalkyne 4 (1.00 mmol) and next CuSO4, 5H2O (25 mg, 0.10 mmol),sodium ascorbate (40 mg, 0.20 mmol) were successively added. Thereaction mixturewas stirred for 12 h at room temperature. Volatileswere evaporated under reduced pressure and the residue purifiedby flash chromatography. When some traces of imidazole wereobserved, EtOAc (20 mL) was added. After washing with water(2 10 mL), the organic layer was dried over MgSO4, filtered andevaporated under reduced pressure to afford the pure derivative of type IIIa.
According to the analysis of related databases, 853909-08-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ouach, Aziz; Pin, Frederic; Bertrand, Emilie; Vercouillie, Johnny; Gulhan, Zuhal; Mothes, Celine; Deloye, Jean-Bernard; Guilloteau, Denis; Suzenet, Franck; Chalon, Sylvie; Routier, Sylvain; European Journal of Medicinal Chemistry; vol. 107; (2016); p. 153 – 164;,
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