New downstream synthetic route of 86521-05-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,86521-05-3, 2-((Trimethylsilyl)ethynyl)pyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 86521-05-3, 2-((Trimethylsilyl)ethynyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C10H13NSi, blongs to pyridine-derivatives compound. COA of Formula: C10H13NSi

2-((Trimethylsilyl)ethynyl)pyridine (175mg, 1.0 mmol) was dissolved in MeOH/Dichloromethane (2mL/lmL). The solution was cooled to 0 C and KOH (112mg, 2.0 mmol) was added. The reaction mixture stirred for 0.5 h, and then quenched with H2O, extracted with Dichloromethane (2×3 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated to give 2-ethynylpyridine (80 mg, 80% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,86521-05-3, 2-((Trimethylsilyl)ethynyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; BALDWIN, John J.; WU, Chengde; SHEN, Chunli; WO2014/124560; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem