Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 884495-38-9, name is 6-Chloro-4-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 884495-38-9
General procedure: To a solution of Intermediate 47B (1.00g. 8.92 mrnol) and 6bromo4 methylnicotinonitrile (1.76 g, 8.92 mmol) in dioxane (20 mL) was added K2C03 (308 g. 22.30mmol) and XANTPHOS (1.03 g, 1.78 mmol) and the resulting reaction mixture was degassed with nitrogen for 5 minutes. Pd2(dha)3 (0.82 g, 089 mmol) was added and the resulting mixture was degassed again for 5 minutes then heated at 100 C for 16 h. The reaction mixture was cooled to ambient temperature, filtered t1i?ough Celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep40 g, 22. 5%MeOHDCM) to obtain Intermediate 47C (120 g, 59.0%) as a pale yellow solid. 1H NMR (300 MHz, DMSO-d6) ppm 2.57 (s. 3 H) 2.65 (t, J= 6.61 Hz, 2 H) 3.55 3.67 (m, 2 H) 4.71 (br. s., I H) 7.80 (s, I H) 7.96 (d, J= 0.76 Hz, I H) 8.47 (s, I H) 8.82 (s, I H). LCMS Qvlethod-D):retention time 086 mm, [M±ij 229.3.
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
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