Synthetic Route of 88912-26-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.88912-26-9, name is 2,5-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.
To a 10000-mL 4-necked round-bottom flask, purged and maintained with an inert atmosphere of nitrogen, was placed 2,5-dichloropyridine-4-carboxylic acid (200 g, 1.04 mol, 1.00 equiv) and tetrahydrofuran (2000 mL), followed by the addition of BH3-THF (3140 mL, 3.00 equiv, 1M) dropwise with stirring at 0 C. The resulting solution was stirred at room temperature for 2 h, quenched by the addition of 2000 mL of water, and extracted with 3×1500 mL of ethyl acetate. The combined organic layers were washed with 2×1500 mL of water, 3×1500 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum to afford 140 g (75percent) of (2,5- dichloropyridin-4-yl)methanol as a white solid.
The chemical industry reduces the impact on the environment during synthesis 88912-26-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; SHORE, Daniel; VOLGRAF, Matthew; ESTRADA, Anthony A.; LYSSIKATOS, Joseph; (153 pag.)WO2018/15410; (2018); A1;,
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