Reference of 941294-57-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.941294-57-1, name is 5-Bromo-2-iodo-4-methylpyridine, molecular formula is C6H5BrIN, molecular weight is 297.92, as common compound, the synthetic route is as follows.
To a suspension of 5-bromo-2-iodo-4-methylpyridine(1g, 3.36 mmol) in NMP (6mL) with an inert atmosphere of argon, KF (0.585 g, 10.07 mmol), Cul (1.92 g, 10.08 mmol) and CF3SiMe3 (2.49 mL, 15.07 mmol) were added. The resulting solution was stirred overnight at 60C. After cooling, the mixture was poured into 12% aqueous ammonia, and then extracted with Et2O. The organic solutions were combined, dried over MgSO4, filtered and concentrated. Purification of the crude residue by normal phase chromatography (0% to 100%, hexane – diethyl ether) afforded the desired product (23% yield) as a yellow oil.
Statistics shows that 941294-57-1 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-iodo-4-methylpyridine.
Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Gonzalez Rodriguez, Jacob; Gual Roig, Silvia; Esteve Trias, Cristina; Vidal Gispert, Laura; EP2738172; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem