In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39856-50-3, 5-Bromo-2-nitropyridine, other downstream synthetic routes, hurry up and to see.
Application of 39856-50-3, Adding some certain compound to certain chemical reactions, such as: 39856-50-3, name is 5-Bromo-2-nitropyridine,molecular formula is C5H3BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39856-50-3.
Preparation XX Synthesis of 4-r6-amino-pyridin-3-ylVpiperazine-l-carboxylic acid tert-butyl ester Step 1. Synthesis of 4-f6-nitro-pyridin-3-yl)-piperazine-l-carboxyric acid tert-butyl ester; A mixture of 5-bromo-2-nitropyridine (4.93g, 24.30 mmol) and tert-butyl piperazine-1-carboxylate (5.Og, 26.7 mmol) in acetonitrile (60ml) was heated at refluxed for 3 days. The solvent was evaporated and the solid residue purified by flash chromatography on silica eluting with EtO Ac/Petrol (1:3) and recrystallised from EtO Ac/Petrol to afford the title compound as an orange solid (5.Og, 67%) (LCMS: Rt 2.8, [M+H]+ 309).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39856-50-3, 5-Bromo-2-nitropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; NOVARTIS AG; WO2008/7123; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem