New downstream synthetic route of COA of Formula: C5H2BrClN2O2

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H2BrClN2O2

The lambda/-[5-(5-amino-6-chloropyridin-3-yl)thiazol-2-yl]acetamide used as a starting material was prepared as follows :-Using an analogous procedure to that described by K. Jouve and J. Bergman, J. Heterocyclic Chem., 2003, 40, 261 except that one equivalent of lithium chloride was used, 2-amino-5-bromo-3-nitropyridine was converted in 84% yield into 5-bromo-2-chloro-3-nitropyridine; 1H nuMR Spectrum: (CDCl3) 8.37 (IH, d), 8.7 (IH, d); which, in turn, was converted into 3-amino-5-bromo-2-chloropyridine; 1H nuMR Spectrum: (CDCl3) 4.17 (2H, br s), 7.18 (IH, d), 7.85 (IH, d).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 67443-38-3, 5-Bromo-2-chloro-3-nitropyridine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/129044; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem