Synthetic Route of 112110-16-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.112110-16-4, name is Dimethyl 5-methylpyridine-2,3-dicarboxylate, molecular formula is C10H11NO4, molecular weight is 209.2, as common compound, the synthetic route is as follows.
EXAMPLE 4 Preparation of 5-Methyl-2,3-pyridinedicarboxylic acid using hydrochloric acid A stirred mixture of 5-methyl-2,3-pyridinedicarboxylic acid dimethyl ester (20.9 g, 0.1 mol), hydrochloric acid (18.2 g, 0.5 mol) and water (72 g) is heated at 70 to 110 C. A mixture of methanol and water and hydrochloric acid is continuously distilled from the reaction mixture and heating is continued until the reaction is complete by chromatographic analysis. The reaction mixture is concentrated in vacuo and diluted with water. The title product is isolated by filtration, washed with water (30 mL) and dried in vacuo. The title product is identified by 1 H-NMR and mass spectroscopy and analyzed by high pressure liquid chromatography to be >96% pure.
Statistics shows that 112110-16-4 is playing an increasingly important role. we look forward to future research findings about Dimethyl 5-methylpyridine-2,3-dicarboxylate.
Reference:
Patent; American Cyanamid Company; US5122608; (1992); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem