Related Products of 197376-47-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 197376-47-9, name is Ethyl 6-Chloropyridine-3-acetate, molecular formula is C9H10ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Phenylboronic acid (3.5 g, 28.7 mmol), ethyl 2-(6-chloropyridin-3-yl)acetate (5.2 g, 26.1 mmol) and tetrakistriphenylphosphine palladium (1.1 g, 0.95 mmol ),was added to a mixture of cyclopentyl methyl ether (80 mL) and 2M sodium carbonate aqueous solution (40 mL), and the mixture was refluxed under a nitrogen gas atmosphere for 15 hours. After cooling to room temperature, deionized water was added, extraction was performed with chloroform, and the solvent was distilled off using a rotary evaporator. The obtained crude product was purified with ethyl acetate (2-(6-phenylpyridin-3-yl)acetate, 3.2 g, 13.3 mmol, 51%) purified by silica gel column chromatography (developing solvent: chloroform).
According to the analysis of related databases, 197376-47-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GUNMA UNIVERSITY; JSR LIFE SCIENCES CORPORATION; JSR CORPORATION; YOSHIHARA, TOSHITADA; TOBITA, SEIJI; ITO, MANABU; MASUDA, NORIO; (44 pag.)JP2018/150245; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem