Related Products of 885276-93-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 885276-93-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate. A new synthetic method of this compound is introduced below.
Synthesis of 5-bromo-N, N-bis(4-methoxybenzyl)pyrazolo[ 1 , 5-a]pyridine-3-carboxamide-26)1-25 1-26[000270] To a suspensions of ethyl 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylate (0.27 g, 1 .0 mmol) in EtOH (5 ml_) was added 6 N KOH (0.3 uL, 2.0 mmol). The reaction was heated to reflux for 3 hours then cooled to room temperature and neutralized to pH 6 with 1 M HCI. The resulting solid was filtered and dried under vacuum to yield 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylic acid (I-25) as a white solid. 1 H NMR (400MHz, DMSO-c/6) delta 8.83 (d, J = 7.6 Hz, 1 H), 8.42 (s, 1 H), 8.21 (d, J = 2.4 Hz, 1 H), 7.30 (dd, J = 2.0, 7.6 Hz, 1 H). MS m/z 240.9, 242.9 (M+1 )+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,885276-93-7, its application will become more common.
Reference:
Patent; IRM LLC; MOLTENI, Valentina; FAN, Yi; LOREN, Jon; SMITH, Jeffrey M.; FLATT, Brenton T.; WO2012/116217; (2012); A1;,
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