Formula: C6H5NO. I found the field of Chemistry very interesting. Saw the article Design and synthesis of novel sugar-based nitrogen-containing heterocycles as potential anticancer agents under microwave in water published in 2019.0, Reprint Addresses Du, K (corresponding author), Shaoxing Univ, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China.; Zheng, H (corresponding author), Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310016, Zhejiang, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.
A series of novel glycosyl nitrogen-containing heterocycles derivatives were designed and synthesized. With the help of microwave, the reaction was carried out in water rapidly and afforded the target compounds in good yields. The acid catalysts that were essential for this kind of reaction under traditional heating method were avoided through this strategy. Preliminary biological evaluation showed that most of the compounds could inhibit the growth of A549 cells, but the inhibition of HepG-2 cells was relatively poor. Notably, compound 2i displayed the best potency with an IC50 value of 3.42 mu M against A549 cell lines, which is comparable with the common anticarcinogen paclitaxel (5.12 mu M). Molecular modeling studies suggested that 2i may bind to the ATP-binding site of epidermal growth factor receptor (EGFR), indicating a rational design strategy. These results provide a starting point for designing glycosyl nitrogen-containing heterocycles as the potential drugs in lung cancer therapy.
Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Liu, J; Wu, CL; Jin, HM; Du, K; Zheng, H or concate me.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem