SDS of cas: 91-02-1. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Discovery of thiosemicarbazone-containing compounds with potent anti- proliferation activity against drug-resistant K562/A02 cells published in 2020.0, Reprint Addresses Gu, XK; Qiu, JY (corresponding author), Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.
Welcome to talk about 91-02-1, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or send Email.. SDS of cas: 91-02-1
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem