The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 143468-13-7, Name is 6-Bromo-1H-pyrrolo[2,3-b]pyridine, SMILES is BrC1=CC=C2C(=N1)[NH]C=C2, in an article , author is Zhang Li, once mentioned of 143468-13-7, Computed Properties of C7H5BrN2.
Synthesis, Characterization, Antitumor Activity, and Theoretical Calculations of Co(II) Complex Based on Pyridine-2,6-dicarboxylic Acid
A new cobalt complex, namely[Co(Hpdc)(bpy)Cl]center dot C2H5OH (bpy=2,2′-bipyridine), was synthesized by using pyridine-2,6-dicarboxylic acid (H(2)pdc) as ligand under hydrothermal condition, and followed by experimental characterization of infrared spectroscopy and X-ray single-crystal diffraction. To deeply reveal the electronic structure of this complex, density functional theory calculations were employed to investigate its charge distribution, electrostatic potential, frontier molecular orbitals, and relevant electronic properties under aqueous condition. Moreover, the antitumor activity of this complex was evaluated by thiazolyl blue tkloYetrazolium bromide (MTT) assay in chronic myelocytic leukemia (K562) and esophageal carcinoma (OE-19) cancer cell lines, and the resulting IC50 values were estimated to be as low as (0.22 +/- 0.05) mu g.mL(-1) and (0.82 +/- 0.16) mu g.mL(-1) (i. e., (0.48 +/- 0.11) mu mol.L-1 and (1.77 +/- 0.35) mu mol.L-1) for K562 and OE-19, respectively, demonstrating its cytotoxic activity against these two cancer cell lines.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem