100-48-1 , The common heterocyclic compound, 100-48-1, name is Isonicotinonitrile, molecular formula is C6H4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
NaOMe (5.4 g, 100 mmol) was added to a stirred solution of 4-pyridinecarbonitrile (10.0 g, 96.1 mmol) in dry MeOH (50 mL) and the mixture stirred at reflux temperature for 2 h. NH4Cl (11.0 g, 211 mmol) was added and the mixture stirred at reflux temperature for 2 h. The solvent was evaporated and the residue crystallised from water to give amidine*HCl 58 (7.54 g, 65percent) as a white powder: mp (H2O) 235-238 ¡ãC (lit.2 mp [H2O] 236-242 ¡ãC); 1H NMR d 9.51 (br s, 4 H, NH, NH2*HCl), 8.87 (dd, J = 4.4, 1.7 Hz, 2 H, H-2, H-6), 7.78 (dd, J = 4.4, 1.7 Hz, 2 H, H-3, H-5).
The synthetic route of 100-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bonnet, Muriel; Flanagan, Jack U.; Chan, Denise A.; Lai, Edwin W.; Nguyen, Phuong; Giaccia, Amato J.; Hay, Michael P.; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3347 – 3356;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem