Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101012-32-2, name is (2-Chloropyridin-3-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H5ClN2
INTERMEDIATE 14 2-[(2-Fluoro-4-iodophenyl)amino1thieno[2,3-?]pyridme-3-carbonitrileTo a solution of (2-chloropyridin-3-yl)acetonitrile {Intermediate 2; 700 mg, 4.59 mmol) and Intermediate 4 (1.28 g, 4.60 mmol) in dry DMSO (15 mL) was added sodium hydride (202 mg, 60% in mineral oil, 5.06 mmol). The mixture was stirred at room temperature for 15 minutes before heating to 9O0C for four hours. The reaction mixture was poured into water (80 mL) and the solid precipitate filtered and washed with water/ ethanol (2:1 mixture, 50 mL) followed by diethyl ether/hexane (1:1 mixture, 20 mL). The solid was dried in a vacuum oven and recrystallised from ethanol/water to give the title compound as a pale brown solid (800 mg, 45%). ?H (DMSOd6) 10.40 (IH, s), 8.37 (IH, dd, J 1.3, 4.6 Hz), 7.83-7.81 (2H, m), 7.64 (IH, d, J 8.3 Hz), 7.44 (IH, dd, J 4.7, 8.0 Hz), 7.33 (IH, dd, J 8.3, 8.3 Hz). LCMS RT 3.08 minutes, (ES”) 394 (M-H)”, (ES+) 396 (M+H)+.
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Reference:
Patent; UCB PHARMA S.A.; WO2009/13462; (2009); A1;,
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