Related Products of 1019021-85-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1019021-85-2, name is 6-Fluoroimidazo[1,2-a]pyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
To a stirring suspension of 6-fluoroimidazo[1 ,2-a]pyridine-3-carboxylic acid (24b) (150 mg, 0.833 mmol) in anhydrous dichloromethane (3 ml_) at 0 C under argon was added dropwise oxalyl chloride (74 muIota_, 0.874 mmol). Then, a drop of anhydrous DMF was added and the reaction mixture was stirred at 0 C for 1 .5 hours. The solvent was concentrated and the crude solid was added to a stirring solution of methyl (3-(3-amino- 4-methylphenyl)-1 ,2,4-oxadiazol-5-yl)methylcarbamate (155) (120 mg, 0.416 mmol) in anhydrous pyridine (3 mL) at 0 C. The reaction was stirred at room temperature under argon for 20 minutes. The solvent was concentrated and the crude product was purified by silica chromatography to give methyl (3-(3-(6-fluoroimidazo[1 ,2-a]pyridine-3- carboxamido)-4-methylphenyl)-1 ,2,4-oxadiazol-5-yl)methylcarbamate (F167). 1 H NMR (400MHz, c/6-DMSO) delta 10.12 (s, 1 H), 9.48 – 9.46 (m, 1 H), 8.63 (s, 1 H), 8.07 (t, J = 5.6 Hz, 1 H), 8.06 (d, J = 1 .6 Hz, 1 H), 7.90 – 7.86 (m , 1 H), 7.82 (dd, J = 2.0, 8.0 Hz, 1 H),7.67 – 7.62 (m, 1 H), 7.50 (d, J = 8.0 Hz, 1 H), 4.57 (d, J = 6.0 Hz, 2H), 3.59 (s, 3H), 2.36 (s, 3H). MS m/z 425.39 (M+1 )+.
According to the analysis of related databases, 1019021-85-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IRM LLC; LIU, Xiaodong; LI, Xiaolin; LOREN, Jon; MOLTENI, Valentina; NABAKKA, Juliet; NGUYEN, Bao; PETRASSI, Hank Michael James; YEH, Vince; WO2013/33116; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem