Synthetic Route of 102368-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.102368-13-8, name is 1,1′-Thiocarbonylbis(pyridin-2(1H)-one), molecular formula is C11H8N2O2S, molecular weight is 232.2584, as common compound, the synthetic route is as follows.
General procedure: Diisothiocyanate with various linker lengths (A6) were prepared according to publishedliterature.2 Commercially available diamine linkers (A5) were converted intodiisothiocyanate using TCDP (1,1?-thiocarbonyldi-2(1H)-pyridone) in single step processquantitative yield. To a solution of A6 (0.32 mmol) in dry pyridine (3 ml), A4 (15 mg,0.063 mmol) was added, followed by DMAP (catalyst amount) in CH2Cl2 (0.2 ml). Themixture was then stirred for 12 h. Volatiles were removed by reduced pressure. Themixture left was purified by column chromatography [0 to 2% methanol in CH2Cl2 (v/v)]to afford desired compound (84 – 92%).
Statistics shows that 102368-13-8 is playing an increasingly important role. we look forward to future research findings about 1,1′-Thiocarbonylbis(pyridin-2(1H)-one).
Reference:
Article; Watkins, Derrick; Gong, Changjun; Kellish, Patrick; Arya, Dev P.; Bioorganic and Medicinal Chemistry; vol. 25; 4; (2017); p. 1309 – 1319;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem