In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 5-Amino-2-(trifluoromethyl)pyridine
6-trifluoromethyl-pyridin-3-ylamine (0.25 g, 1 .54 mmol) was added to a mixture of sodium hydride (0.22 g, 9.16 mmol) and N,N-dimethylformamide (2 mL) at 25 – 30 C under nitrogen gas and the reaction mixture was stirred for 15 – 20 min. Compound of example 2 (0.44 g, 1 .7 mmol) was added to the reaction mixture and was stirred for 6 – 8 h. The reaction mixture was cooled to 10 C and methanol (1 .2 mL) was added slowly. A solution of chilled 20 % ammonium chloride solution (10 mL) was added drop-wise to the reaction mixture at 10 C and was stirred for 25 – 30 min. The precipitated product was filtered, and was washed with water followed by petroleum ether. The resulting product was dried at 45 – 50 C for 20 – 22 h. Yield: 0.4 g (68.96 %); 1H NMR (300 MHz, DMSO-d6): delta 10.28 (s, 1 H), 8.9 (s, 1 H), 8.8 (s, 1 H), 8.58 (d, 1 H, 8.7 Hz), 7.87 (d, 1 H, 8.7 Hz), 7.66 (d, 1 H, 9 Hz), 7.32 (s, 1 H), 7.1 (d, 1 H, 8.4 Hz), 3.86 (s, 6H, 6.3 Hz); MS (ES+): 377 (M+1 ).
The synthetic route of 106877-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana, Sanjay; HARIHARAN, Sivaramakrishnan; BOKKA, Ravishankar; AWARE, Valmik, Sopan; MANOHAR, Sonal; SONAWANE, Vinay; CHENNAMSETTY, Suneelmanoharbabu; KALE, Ganesh; THOMAS, Becky, Mary; TRIVEDI, Jacqueline, Vinodkumar; WO2013/175415; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem