In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, the common compound, a new synthetic route is introduced below. Recommanded Product: 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide
EXAMPLE 14B 1-tert-butyl-3-methyl 4-{[(trifluoromethyl)sulfonyl]oxy}-5,6-dihydropyridine-1,3(2H)-dicarboxylate A solution of Example 14A (958 mg, 3.73 mmol) in dichloromethane (10 mL) at 0 C. was treated with diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), warmed to room tempeature overnight, treated with additional diisopropylethylamine (2 mL) and 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (2.67 g, 7.46 mmol), stirred for 5 days, and partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5 to 10% ethyl acetate/hexanes to provide the desired product (1.02 g, 70%). MS (DCI/NH3) m/e 407 (M+NH4)+; 1H NMR (300 MHz, CDCl3) delta4.27 (m, 2H), 3.84 (s, 3H), 3.63 (t, J=5.8 Hz, 2H), 2.52 (m, 2H), 1.48 (s, 9H).
The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gwaltney II, Stephen L.; Nelson, Lissa T.J.; O’Connor, Stephen J.; Sham, Hing L.; Sullivan, Gerard M.; Wang, Weibo; US2003/216441; (2003); A1;,
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