Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-60-4, name is Picolinaldehyde. A new synthetic method of this compound is introduced below., 1121-60-4
General procedure: Ce(NO3)3¡¤6H2O (0.15 mmol) was added to a mixture of the diamine 1 (0.5 mmol) and the appropriate aldehyde 2 (0.6 mmol) in DMF (3 mL). The reaction mixture was stirred at 80C. The reaction progress was monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to rt, water (15 mL) was added and the resulting mixture was extracted with EtOAc (3 10 mL). The combined organic phases were successively washed with water and brine, and dried over anhydrous MgSO4. After filtration, the solvent was removed under reduced pressure. The product was purified chromatographically (hexane- EtOAc, 70:30).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-60-4, Picolinaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Martins, Guilherme M.; Puccinelli, Thiago; Gariani, Rogerio A.; Xavier, Fernando R.; Silveira, Claudio C.; Mendes, Samuel R.; Tetrahedron Letters; vol. 58; 20; (2017); p. 1969 – 1972;,
Pyridine – Wikipedia,
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