With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13228-40-5, name is 2-(2-Pyridyl)indole, molecular formula is C13H10N2, molecular weight is 194.2319, as common compound, the synthetic route is as follows.Safety of 2-(2-Pyridyl)indole
General procedure: A sealed tube was charged with 4 (0.20 mmol), 2 (0.30 mmol), CeCl3·7H2O (0.02 mmol). Then 2 ml of ethanol was added to the reaction system. The reaction mixture was stirred at 120 C. The reaction was monitored by TLC until the 4 was completely consumed (about 12h). The solvent was removed under reduced pressure. The residue was purified through column chromatography using silica gel to give 5.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13228-40-5, 2-(2-Pyridyl)indole, and friends who are interested can also refer to it.
Reference:
Article; Feng, Cheng-Tao; Zhu, Hui-Zhi; Li, Zhong; Luo, Zaigang; Wu, Song-Song; Ma, Shi-Tang; Tetrahedron Letters; vol. 57; 7; (2016); p. 800 – 803;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem