Adding a certain compound to certain chemical reactions, such as: 149246-87-7, 5-(Pyridin-3-yl)-1H-pyrazol-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-(Pyridin-3-yl)-1H-pyrazol-3-amine, blongs to pyridine-derivatives compound. Safety of 5-(Pyridin-3-yl)-1H-pyrazol-3-amine
General procedure: 1H-Pyrazol-5-amine 1 (1 equiv.), 3-oxopropanenitrile 2 (1 equiv.), benzaldehyde 3 (1 equiv.), and Et3N (2 equiv.) were stirred in DMF (1 M) at 90 °C for 16 h. The volatiles were removed under reduced pressure (or positive N2 (g) pressure). Sodium nitrite (3 equiv.) and acetic acid (134 equiv.) were added to the crude material, and the reaction mixture was stirred for 10 min. The volatiles were removed under reduced pressure (or positive N2 (g) pressure), and the crude reaction mixture was subjected to silica gel column chromatography with ethyl acetate in hexanes.
The synthetic route of 149246-87-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hill, Matthew D.; Synthesis; vol. 48; 14; (2016); p. 2201 – 2204;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem