With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15128-82-2, name is 2-Nitropyridin-3-ol, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.name: 2-Nitropyridin-3-ol
(Example 2 Synthesis of Compounds I-113 and 1-144) [Show Image]Step 1 A solution of 2-nitropyridin-3-ol (6) (16.0 g, 114 mmol) in dimethylformamide (120 mL) was cooled to 0C, and then N-bromosuccinimide (26.4 g, 1.48 mmol) was gradually added thereto. The solution was then stirred at 0 C for 1 hour, and at room temperature for another 2 hours. The reaction solution was concentrated in vacuo, and then the residue was washed with diethyl ether. The filtrate was poured to aqueous saturated sodium bicarbonate, followed by extraction with diethyl ether. The organic layer was washed sequentially with water and saturated brine, then dried with anhydrous magnesium sulfate, and concentrated in vacuo to yield the subject compound (7) (15.5 g, 62%) as a white powder.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15128-82-2, 2-Nitropyridin-3-ol, and friends who are interested can also refer to it.
Reference:
Patent; Shionogi & Co., Ltd.; EP2341052; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem