16013-85-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16013-85-7 as follows.
Intermediate 6: 2,6-dibromo-3-nitropyridine (Scheme 12); A mixture of commercially available 2,6-dichloro-3-nitropyridine (10.0 g; 51.8 mmol) and 33 w% HBr/AcOH (120 mL) is heated at 80C for 3h. The solution is concentrated in vacuo, the resulting residue is taken into EtOAc and ished with saturated aqueous sodium bicarbonate. The organic phase is dried over sodium sulfate and concentrated in vacuo. The resulting product 14.4 g (99%) is used without further purification (Intermediate 6). GC/MS: 94% purity, tR 7.56 min (tR(SM) 6.93 min), m/z (CsI^B^) 280/282/284 (M, 38), 222/224/226 (35), 76 (100) Finnegan LCQ.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16013-85-7, its application will become more common.
Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/24666; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem