Application of 1620-71-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1620-71-9, name is 5-Methyl-2-(trifluoromethyl)pyridine, molecular formula is C7H6F3N, molecular weight is 161.12, as common compound, the synthetic route is as follows.
Step A: 5-methyl-2-(trifluoromethyl)pyridine 1-oxide 5-methyl-2-trifluoromethyl-pyridine (commercially available, 0.164g) was dissolved in dichloromethane (5 mL). Meta-chloroperoxybenzoic acid (m-CPBA, 0.486 g) was added, and the mixture was stirred 48 hours at ambient (rt) temperature. The solvent was remove under reduce pressure and the crude product was purified by chromatography (solvent: isohexane/diethyl ether 7/3 to diethylether) to give the title compound (120mg) as a white solid. 1H NMR (300MHz, CDCI3): oe (ppm) 8.17 (s, 1H), 7.57 (d,1H), 7.16 (d, 1H), 2.38 (s, 3H) ppm.
Statistics shows that 1620-71-9 is playing an increasingly important role. we look forward to future research findings about 5-Methyl-2-(trifluoromethyl)pyridine.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; HALL, Roger Graham; GOEGH, Tibor; JUNG, Pierre Joseph Marcel; EDMUNDS, Andrew; JEANGUENAT, Andre; MUEHLEBACH, Michel; STOLLER, Andre; (98 pag.)WO2016/20286; (2016); A1;,
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