In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 182924-36-3, name is 5-(Bromomethyl)-2-chloropyridine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H5BrClN
To a solution of 323 mg (1.10 mmol) of (2-AMINO-5-PROPARGYLOXY-PHENYL)-4- isopropyl-phenyl) -methanone and 250 mg (1.21 mmol) of 2-bromomethyl-2-chloro- pyridine (step A) in 2 ml 1, 3-dimethyl-2-imidazolidinone (DMEU) 213 mg (1.54 mmol) of potassium carbonate are added. The reaction is complete after stirring for 2 h at 60 C. The cooled yellow suspension is distributed between ethyl acetate and bicarbonate solution. Flash chromatography (hexane/ethyl acetate) affords a yellow solid. m. p. 96 C. ‘H-NMR (300 MHz, CDC13) : 8.49 (t, 1H), 8.40 (d, 1H), 7.67 (dd, 1H), 7.61 (d, 2H), 7.31 (d, 2H), 7.30 (d, 1H), 7.23 (d, 1H), 7.08 (dd, 1H), 6.59 (d, 1H), 4.53 (d, 2H), 4.48 (d, 2H), 2.99 (HEPT, 1H), 2.48 (t, 1H), 1.31 (d, 6H). MS: 419 (M+L)
The synthetic route of 182924-36-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/56365; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem