As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid, molecular formula is C6H5NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 19621-92-2
General procedure: To a stirred solution of 3-hydroxypicolinic acid (100 mg, 0.72 mmol), hydroxybenzotriazole (abbreviated HOBt, 194 mg, 1.44 mmol), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI, 276 mg, 1.44 mmol) in dimethylformamide (DMF, 5 mL) at rt was added N,N-diisopropylethylamine (DIPEA, 0.25 mL, 1.44 mmol) and (4-fluorophenyl) methanamine (0.18 mL, 1.44 mol). The reaction mixture was stirred at 50 C in microwave reactor for 2 h. After removal of most of the DMF, the residue which was purified by chromatography using ether/ethyl acetate (3:1) as eluent to give compound 1a (2a) as a white solid (166 mg, 94%), m.p. 71-73 C.
With the rapid development of chemical substances, we look forward to future research findings about 19621-92-2.
Reference:
Article; Zhang, Feng-Hua; Debnath, Bikash; Xu, Zhong-Liang; Yang, Liu-Meng; Song, Li-Rui; Zheng, Yong-Tang; Neamati, Nouri; Long, Ya-Qiu; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1051 – 1063;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem